Consequences of long term-Confinement and Hypobaric HypOxia on Immunity in the Antarctic Concordia Environment (CHO2ICE III)

Hypotheses: 1) increased hypersensitivity developed during over-wintering are associated with early infections, viral reactivation and the microbiota found in Concordia, 2) when the crew is re-exposed to the non-Antarctic environment after over-wintering, hypersensitivities are increased and 3) the alteration of the immune response that occurs during over-wintering is individually regulated based on sympatho-androgenic activation and sleep disturbance.